Devising new strategies to track and prevent breast cancer development in BRCA mutation carriers
Principal Investigator: Joan Brugge | Affiliation: Harvard University
Research Keywords
Precancer biology, immunology
Research Questions
- How do basal and luminal breast cells contribute to BRCA-related cancers?
- How do BRCA tumor cells evolve?
- What are the molecular defects during tumor evolution?
- How do we detect cancer evolution in carriers?
- How do we intercept and eradicate tumor development?
Specific Aims
- Aim 1:
- Aim 2:
- Aim 3:
Methods
- CyCIF
- Mouse models
- Single cell sequencing
- Tissue microarray